The 49ers are likely to be without George Kittle, Christian McCaffrey and Deebo Samuel for Sunday's game at the Rams.

SANTA CLARA, Calif. — The San Francisco 49ers have played games without Deebo Samuel Sr. in the last year and a half. And ...

The 49ers are partly to blame for why Christian McCaffrey will be out at least four games and possibly more as he nurses ...

Greg Papa joins "49ers Talk" host Matt Maiocco and discusses if 49ers wide receiver Brandon Aiyuk will step up in Rams ...

San Francisco 49ers star Christian McCaffrey could miss more than the minimum of four games required on injured reserve, ...

ESPN sources: 49ers officially are placing All-Pro RB Christian McCaffrey on injured reserve due to his calf tightness and ...

The San Francisco 49ers have placed All-Pro running back Christian McCaffrey on injured reserve because of his lingering calf ...

The 49ers revealed their status reports Friday for their injured players ahead of Sunday’s visit to the Los Angeles Rams.

Now comes the hard part for Kyle Shanahan — devising a game plan without Deebo Samuel and Christian McCaffrey.

With injuries sidelining their star athletes, can the 49ers rally together to secure a crucial win against the desperate Rams ...

"Nobody knows" when Christian McCaffrey will be ready to return from injured reserve, 49ers coach Kyle Shanahan said Sunday.

There was plenty of blame to go around in all phases for the 49ers Sunday in a 23-17 road loss to the Minnesota Vikings.