This will be a week of Davids facing Goliaths as far as betting is concerned: Seven of the 16 matchups opened with the favorite giving up at least 6.5 points to the underdog. Fire

The San Francisco 49ers and Los Angeles Rams have aspirations of winning the NFC West and making another Super Bowl run, but both are dealing with significant losses on offense entering Week 3 when they go head-to-head.

After an atrocious offensive performance in Week 1, the Cleveland Browns bounced back to defeat the Jacksonville Jaguars in Week 2. While the offense still looked underwhelming, with quarterback Deshaun Watson compiling only 5.